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2015. 8. 23. 15:38

[2015-May-21] FDA approves Stiolto™* Respimat® as once-daily maintenance treatment for COPD

https://www.boehringer-ingelheim.com/news/news_releases/press_releases/2015/26_may_2015_copd.html





Stiolto_Respimat.cdx


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http://dx.doi.org/10.1016/0024-3205(93)90312-Q


Bernd Disse, Georg A. Speck, Karl Ludwig Rominger, Theodore J. Witek Jr., and Rudolf Hammer, Tiotropium (SPIRIVA™): Mechanistical considerations and clinical profile in obstructive lung disease, Life Sci.1999, 64 (6-7), pp 457-464

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Thierry Bouyssou, Christoph Hoenke, Klaus Rudolf, Philipp Lustenberger, Sabine Pestel, Peter Sieger, Ralf Lotz, Claudia Heine, Frank H. Büttner, Andreas Schnapp, and Ingo Konetzki, Discovery of olodaterol, a novel inhaled β2-adrenoceptor agonist with a 24 h bronchodilatory efficacy, Bioorg. Med. Chem. Lett., 2010, 20 (4)pp 1410–1414

http://dx.doi.org/10.1016/j.bmcl.2009.12.087


T. Bouyssou, P. Casarosa, E. Naline, S. Pestel, I. Konetzki, P. Devillier, and A. Schnapp, Pharmacological Characterization of Olodaterol, a Novel Inhaled β2-Adrenoceptor Agonist Exerting a 24-Hour-Long Duration of Action in Preclinical Models, J. Pharmacol. Exp. Ther., 2010, 334 (1), pp 53-62

http://dx.doi.org/10.1124/jpet.110.167007


Mario Cazzola, and Mathieu Molimard, The scientific rationale for combining long-acting β2-agonists and muscarinic antagonists in COPD, Pulm. Pharmacol. Ther., 201023 (4), pp 257–267

http://dx.doi.org/10.1016/j.pupt.2010.03.003


Mario Cazzola Luigino Calzetta and Maria Gabriella Matera, β2-adrenoceptor agonists: current and future direction, British J. Pharmacol., 2011, 163 (1), pp 4-17

http://dx.doi.org/10.1111/j.1476-5381.2011.01216.x


Yasser Mushtaq, The COPD pipeline, Nat. Rev. Drug Discov., 201413 (4), pp 253–254

http://dx.doi.org/10.1038/nrd4254


Andrew C. Kruse, Brian K. Kobilka, Dinesh Gautam, Patrick M. Sexton, Arthur Christopoulos and Jürgen Wess, Muscarinic acetylcholine receptors: novel opportunities for drug development, Nat. Rev. Drug Discov., 201413 (7), pp 549–560

http://dx.doi.org/10.1038/nrd4295


Paolo Montuschi and Giovanni Ciabattoni, Bronchodilating Drugs for Chronic Obstructive Pulmonary Disease: Current Status and Future Trends, J. Med. Chem., 2015, 58 (10), pp 4131–4164

http://dx.doi.org/10.1021/jm5013227